The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 22, 2005
Filed:
May. 11, 2001
Robert Henry Hesse, Winchester, MA (US);
Sundara Katugam Srinivasasetty Setty, Cambridge, MA (US);
Maurice Murdoch Pechet, Cambridge, MA (US);
Michael Gile, Methuen, MA (US);
Robert Henry Hesse, Winchester, MA (US);
Sundara Katugam Srinivasasetty Setty, Cambridge, MA (US);
Maurice Murdoch Pechet, Cambridge, MA (US);
Michael Gile, Methuen, MA (US);
Research Institute for Medicine and Chemistry, Inc., Cambridge, MA (US);
Abstract
Compounds of formula (I) in which: Rrepresents a hydrogen atom or an O-protecting group; Rrepresents a hydroxyl, lower alkoxy, carboxaldehyde, lower alk-1-enyl or hydroxy- or lower alkoxy-substituted lower alkyl group; Rrepresents a methyl group having α- or β-configuration; X represents a Calkylene group or a valence bond; Y represents a carboxaldehyde group or a group of formula —C(R)(R)ORwhere Ris as defined above and Rand R, which may be the same or different, are each selected from hydrogen atoms, alkyl, alkenyl and alkynyl groups such that the total carbon content of Rand Rdoes not exceed three atoms, with the proviso that X is a valence bond when both Rand Rare other than hydrogen; and the dotted line signifies that a double bond may optionally be present at the 16(17)-position exhibit potent cell modulating activity, including antiproliferative and antiangiogenic effects.