The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 01, 2005
Filed:
Mar. 04, 2002
Xiaokui Zhang, New York, NY (US);
Curt Horvath, New York, NY (US);
Melissa H. Wrzeszczynska, New York, NY (US);
James E. Darnell, Jr., Larchmont, NY (US);
Xiaokui Zhang, New York, NY (US);
Curt Horvath, New York, NY (US);
Melissa H. Wrzeszczynska, New York, NY (US);
James E. Darnell, Jr., Larchmont, NY (US);
The Rockefeller University, New York, NY (US);
Abstract
The present invention relates to methods for identifying interacting regions of transcription factors, and methods for identifying agents which modulate the interactions, useful for affecting gene regulation, for example, cellular transformation. A site within residues 130-154 and within residues 343-358 in Stat3 were found to interact with the transcription factor c-Jun. On c-Jun, a site within residues 105 and 334, and more particularly, between 105 and 263, interact with Stat3. These sites of interactions permit methods for identifying agents which modulate the interaction between these transcription factors to modulate gene transcription.