The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 11, 2005
Filed:
Sep. 17, 2002
H. Ralph Snodgrass, Powell, OH (US);
Joseph Cioffi, New Albany, OH (US);
Thomas Joel Zupancic, Worthington, OH (US);
Alan Wayne Shafer, Lancaster, OH (US);
H. Ralph Snodgrass, Powell, OH (US);
Joseph Cioffi, New Albany, OH (US);
Thomas Joel Zupancic, Worthington, OH (US);
Alan Wayne Shafer, Lancaster, OH (US);
Indevus Pharmaceuticals, Inc., Lexington, MA (US);
Abstract
The present invention relates to a variant from of the receptor for the obese gene product. In particular, the invention relates to methods of detecting this receptor variant in cells and tissues of obese individuals. In addition, it relates to methods of inhibiting or down regulating expression of this variant in cells to augment their responsiveness to weight regulation by leptin as well as methods of using compounds to directly activate signal transduction pathways associated with this ligand-receptor system. In addition, the invention relates to identifying compounds capable of supplementing biological activity of leptin on cells expressing a leptin receptor variant.