The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 20, 2005
Filed:
Mar. 29, 2000
Frank Mckeon, Boston, MA (US);
Annie Yang, Boston, MA (US);
Massimo Loda, Belmont, MA (US);
Sabina Signorretti, Brookline, MA (US);
Christopher Crum, Brookline, MA (US);
Frank McKeon, Boston, MA (US);
Annie Yang, Boston, MA (US);
Massimo Loda, Belmont, MA (US);
Sabina Signorretti, Brookline, MA (US);
Christopher Crum, Brookline, MA (US);
President & Fellows of Harvard College, Cambridge, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Abstract
This application describes the cloning of p63, a gene at chromosome 3q27-29, that bears homology to the tumor suppressor p53. The p63 gene encodes at least six different isotypes. p63 was detected in a variety of human and mouse tissue and demonstrates remarkably divergent activities, such as the ability to transactivate p53 reporter genes and induce apoptosis. Isotopes of p63 lacking a transactivation domain act as dominant negatives towards the transactivation by p53 and p63.