The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 16, 2005
Filed:
Feb. 26, 2002
Marco Guida, San Diego, CA (US);
Jeff Hall, Carlsbad, CA (US);
William P. Petros, Morgantown, WV (US);
James J. Vredenburgh, Chapel Hill, NC (US);
Oliver M. Colvin, Chapel Hill, NC (US);
Jeffrey R. Marks, Hillsborough, NC (US);
Marco Guida, San Diego, CA (US);
Jeff Hall, Carlsbad, CA (US);
William P. Petros, Morgantown, WV (US);
James J. Vredenburgh, Chapel Hill, NC (US);
Oliver M. Colvin, Chapel Hill, NC (US);
Jeffrey R. Marks, Hillsborough, NC (US);
Genaissance Pharmaceuticals, Inc., New Haven, CT (US);
Duke University, Durham, NC (US);
Abstract
Methods for detecting variant genes having a polymorphism associated with reduced metabolism of a substrate selected from the group consisting of a CYP3A4 substrate, a CYP3A5 substrate and a GSTM1 substrate in an individual are disclosed. The methods are genotyping methods to identify specific polymorphisms which have been found to be associated with reduced metabolism of chemotherapeutic agents, such as cyclophosphamide and BCNU. Also disclosed are novel polymorphic nucleic acid molecules useful in the methods of the invention.