The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 2005
Filed:
Jun. 22, 2001
Clifton E. Barry, Iii, Bethesda, MD (US);
Andrea E. Debarber, Rockville, MD (US);
Khisimuzi Mdluli, Seattle, WA (US);
Linda-gail Bekker, New York, NY (US);
Clifton E. Barry, III, Bethesda, MD (US);
Andrea E. DeBarber, Rockville, MD (US);
Khisimuzi Mdluli, Seattle, WA (US);
Linda-Gail Bekker, New York, NY (US);
Abstract
The invention relates to the discovery that a putative gene ofwith no previously identified function is responsible for the ability of the bacterium to activate thioamide drugs. Sincehas a low rate of synonymous mutations, all mutations in this gene, identified as Rv3854c and now termed 'EtaA,' are expected to inhibit the ability of a bacterium with the mutation to activate a thioamide or thiocarbonyl drug. Thus, detecting a bacterium with a mutation in this gene indicates that the bacterium is resistant to treatment with thioamides.