The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 2005
Filed:
Jul. 08, 1999
Carl H. June, Rockville, MD (US);
Craig B. Thompson, Chicago, IL (US);
Gary J. Nabel, Ann Arbor, MI (US);
Gary S. Gray, Brookline, MA (US);
Paul D. Rennert, Holliston, MA (US);
Carl H. June, Rockville, MD (US);
Craig B. Thompson, Chicago, IL (US);
Gary J. Nabel, Ann Arbor, MI (US);
Gary S. Gray, Brookline, MA (US);
Paul D. Rennert, Holliston, MA (US);
Genetics Institute, Inc., Cambridge, MA (US);
Regents of the University of Michigan, Ann Arbor, MI (US);
The United States of America as represented by the Secretary of the Navy, Washington, DC (US);
Abstract
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.