The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 2005
Filed:
Oct. 03, 2002
Wenxi Pan, Exton, PA (US);
Tianbao LU, Kennett Square, PA (US);
Thomas P. Markotan, Morgantown, PA (US);
Bruce E. Tomczuk, Collegeville, PA (US);
Wenxi Pan, Exton, PA (US);
Tianbao Lu, Kennett Square, PA (US);
Thomas P. Markotan, Morgantown, PA (US);
Bruce E. Tomczuk, Collegeville, PA (US);
3-Dimensional Pharmaceuticals, Inc., Exton, PA (US);
Abstract
Phenyl acetamide compounds are described, including compounds ofor a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R-R, R, B, Y and W are set forth in the specification. The compounds of the invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as thrombin and factor Xa. Compositions for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation are described. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage, such as catheters, blood dialysis machines, blood collection syringes and tubes, blood lines and stents. Additionally, the compounds can be detectably labeled and employed for in vivo imaging of thrombi.