The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 2005
Filed:
Jul. 21, 2003
Tao Guo, Dayton, NJ (US);
Koc-kan Ho, West Windsor, NJ (US);
Edward Mcdonald, Reigate, GB;
Roland Ellwood Dolle, King of Prussia, PA (US);
Kurt W. Saionz, Cranford, NJ (US);
Steven G. Kultgen, Dayton, NJ (US);
Ruiyan Liu, Skillman, NJ (US);
Guizhen Dong, Dayton, NJ (US);
Peng Geng, Edison, NJ (US);
Anton Egbert Peter Adang, Eindhoven, NL;
Nicole Corine Renee Van Straten, Berghem, NL;
Tao Guo, Dayton, NJ (US);
Koc-Kan Ho, West Windsor, NJ (US);
Edward McDonald, Reigate, GB;
Roland Ellwood Dolle, King of Prussia, PA (US);
Kurt W. Saionz, Cranford, NJ (US);
Steven G. Kultgen, Dayton, NJ (US);
Ruiyan Liu, Skillman, NJ (US);
Guizhen Dong, Dayton, NJ (US);
Peng Geng, Edison, NJ (US);
Anton Egbert Peter Adang, Eindhoven, NL;
Nicole Corine Renee Van Straten, Berghem, NL;
Pharmacopeia Drug Discovery, Inc., Princeton, NJ (US);
Abstract
The invention relates to bisaryl derivatives of the formula I,wherein (R,R) is selected from (H,H), O, (H,CH), (H,OH) and (H,CN); Ar is substituted phenyland A is a group of formula II, III, IV or V: An example is (3S,6S)-1-N-(7-phenylheptyl)-3-(4-(3,4,5-trimethoxyphenyl)benzyl)-4-N-methyl-6-methyl-2,5-dioxo-1,4-piperazine: The compounds of the invention have FSH receptor modulatory activity and can be used for the control of fertility, for contraception or for treatment of hormone-dependent disorders.