The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 2005
Filed:
Jun. 03, 2002
Tom J. Parry, Walkersville, MD (US);
Les Sekut, Ijamsville, MD (US);
Craig A. Rosen, Laytonsville, MD (US);
Vivian R. Albert, Rockville, MD (US);
Indrajit Sanyal, Bethesda, MD (US);
Lili Huang, Burlington, MA (US);
Charles R. Wescott, Belmont, MA (US);
Tom J. Parry, Walkersville, MD (US);
Les Sekut, Ijamsville, MD (US);
Craig A. Rosen, Laytonsville, MD (US);
Vivian R. Albert, Rockville, MD (US);
Indrajit Sanyal, Bethesda, MD (US);
Lili Huang, Burlington, MA (US);
Charles R. Wescott, Belmont, MA (US);
Human Genome Sciences, Inc., Rockville, MD (US);
Abstract
Binding polypeptides comprising specific amino acid sequences are disclosed that specifically bind ACE-2 protein or ACE-2-like polypeptides. The binding polypeptides can be used in methods of the invention for detecting, isolating, or purifying ACE-2 protein or ACE-2-like polypeptides in solutions or mixtures, or biological samples. The invention also relates to nucleic acid molecules encoding these ACE-2 binding polypeptides, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention also relates to methods and compositions for detecting, diagnosing, prognosing, preventing, treating or ameliorating a disease or disorder associated with aberrant ACE-2 or ACE-2 receptor expression or inappropriate function of ACE-2 or ACE-2 receptor, comprising use of ACE-2 binding polypeptides or fragments or variants thereof, that specifically bind to ACE-2.