The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 24, 2005
Filed:
May. 26, 2000
R. Blake Pepinsky, Arlington, MA (US);
Chenhui Zeng, Sudbury, MA (US);
Darren P. Baker, Hingham, MA (US);
Dingyi Wen, Waltham, MA (US);
Kevin P. Williams, Natick, MA (US);
Ellen A. Garber, Cambridge, MA (US);
Kathryn L. Strauch, Bedford, MA (US);
Frederick R. Taylor, Milton, MA (US);
Paul H. Weinreb, Methuen, MA (US);
Russell C. Petter, Stow, MA (US);
Alphonse Galdes, Lexington, MA (US);
Jeffrey Porter, Cambridge, MA (US);
R. Blake Pepinsky, Arlington, MA (US);
Chenhui Zeng, Sudbury, MA (US);
Darren P. Baker, Hingham, MA (US);
Dingyi Wen, Waltham, MA (US);
Kevin P. Williams, Natick, MA (US);
Ellen A. Garber, Cambridge, MA (US);
Kathryn L. Strauch, Bedford, MA (US);
Frederick R. Taylor, Milton, MA (US);
Paul H. Weinreb, Methuen, MA (US);
Russell C. Petter, Stow, MA (US);
Alphonse Galdes, Lexington, MA (US);
Jeffrey Porter, Cambridge, MA (US);
Curis, Inc., Cambridge, MA (US);
Biogen Idec Inc., Cambridge, MA (US);
Abstract
Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide variety of chemical reactions that append a hydrophobic structure to the protein. The preferred protein is of mammalian origin and is selected from the group consisting of Sonic, Indian, and Desert hedgehog. The hydrophobic moiety is used as a convenient tether to which may be attached a vesicle such as a cell membrane, liposome, or micelle.