The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 24, 2005
Filed:
Jan. 28, 1999
Gary R Braslawsky, San Diego, CA (US);
Nabil Hanna, Rancho Santa Fe, CA (US);
Kandasamy Hariharan, San Diego, CA (US);
Michael J Labarre, San Diego, CA (US);
Tri B Huynh, San Diego, CA (US);
Gary R Braslawsky, San Diego, CA (US);
Nabil Hanna, Rancho Santa Fe, CA (US);
Kandasamy Hariharan, San Diego, CA (US);
Michael J LaBarre, San Diego, CA (US);
Tri B Huynh, San Diego, CA (US);
Biogen Idec, Inc., San Diego, CA (US);
Abstract
The present invention relates to a novel process for the preparation of biologically active antibody dimers in a pharmaceutically acceptable composition. The dimers can be composed of two antibody molecules having the same antigen binding specificity and linked through reducible, disulfide, or a non-reducible thioether, bond (homodimer). Alternatively, the dimers can be composed of two different antibody molecules having binding specificity for two distinct antigens (heterodimer). These dimers are useful for inducing hyper-cross-linking of membrane antigens. The present invention further relates to the use of biologically active antibody dimers for the preferential killing or inhibition of selected cell populations in the treatment of diseases such as cancer and autoimmune disorders.