The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 10, 2005
Filed:
Oct. 09, 2001
Roger Williams, Cambridge, GB;
Christian Ried, Berlin, DE;
Edward H. Walker, Chesterton, GB;
Len Stephens, Horseheath, GB;
Roger Williams, Cambridge, GB;
Christian Ried, Berlin, DE;
Edward H. Walker, Chesterton, GB;
Len Stephens, Horseheath, GB;
Warner-Lambert Company, Morris Plains, CA (US);
Onyx Pharmaceuticals, Inc., Richmond, CA (US);
Abstract
The present invention relates PI3K crystals, polypeptide muteins, polypeptide fragments, antibodies thereto, nucleic acids coding for these polypeptides, methods of modifying PI3Kγ activity, and methods of modulating PI3Kγ activity. These include polypeptides and methods thereof, relating to, e.g., phospholipid binding, lipid kinase activity, modulating Ras activity in activating the PI3Kγ, binding of PI3Kγ to cell membranes, and modulating protein—protein interactions with PI3Kγ.