The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 22, 2005
Filed:
Oct. 26, 2001
Gabriel Nunez, Ann Arbor, MI (US);
Naohiro Inohara, Ann Arbor, MI (US);
Yasunori Ogura, Ann Arbor, MI (US);
Judy Cho, Chicago, IL (US);
Dan L. Nicolae, Chicago, IL (US);
Denise Bonen, Chicago, IL (US);
Gabriel Nunez, Ann Arbor, MI (US);
Naohiro Inohara, Ann Arbor, MI (US);
Yasunori Ogura, Ann Arbor, MI (US);
Judy Cho, Chicago, IL (US);
Dan L. Nicolae, Chicago, IL (US);
Denise Bonen, Chicago, IL (US);
Regents of the University of Michigan, Ann Arbor, MI (US);
Abstract
The present invention relates to intracellular signalling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides isolated nucleotide sequence encoding Nod2, isolated Nod2 peptides, antibodies that specifically bind Nod2, methods for the detection of Nod2, and methods for screening compounds for the ability to alter Nod2 associated signal transduction. The present invention also provides Nod2 variant alleles. The present invention further provides methods of identifying individuals at increased risk of developing Crohn's disease.