The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2005
Filed:
Nov. 04, 1999
Applicants:
William D. Huse, Del Mar, CA (US);
Jeffry D. Watkins, Encinitas, CA (US);
Herren Wu, San Diego, CA (US);
Inventors:
William D. Huse, Del Mar, CA (US);
Jeffry D. Watkins, Encinitas, CA (US);
Herren Wu, San Diego, CA (US);
Assignee:
Ixsys, Inc., San Diego, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1500 ;
U.S. Cl.
CPC ...
Abstract
The invention provides a method of conferring donor CDR binding affinity onto an antibody acceptor variable region framework. The invention also provides a method of simultaneously grafting and optimizing the binding affinity of a variable region binding fragment. A method of optimizing the binding affinity of an antibody variable region is also provided.