The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 25, 2005
Filed:
May. 02, 2003
Clayton V. Mcneff, Anoka, MN (US);
Peter W. Carr, St. Paul, MN (US);
Steven J. Rupp, Minnetonka, MN (US);
Dwight R. Stoll, Anoka, MN (US);
Danielle R. Hawker, Shakopee, MN (US);
Lorinda D. Zigan, Browerville, MN (US);
Kerry G. Johnson, Minneapolis, MN (US);
Clayton V. McNeff, Anoka, MN (US);
Peter W. Carr, St. Paul, MN (US);
Steven J. Rupp, Minnetonka, MN (US);
Dwight R. Stoll, Anoka, MN (US);
Danielle R. Hawker, Shakopee, MN (US);
Lorinda D. Zigan, Browerville, MN (US);
Kerry G. Johnson, Minneapolis, MN (US);
ZirChrom Separations, Inc., Anoka, MN (US);
Abstract
The present invention describes the use of porous metal oxides for the preparative purification of antibodies and biomolecules within a range of particle physical characteristics. Typically, particles from 15 to 100 microns in average diameter with pores sizes ranging from 400 to 600 angstroms and surface areas from 10 to 50 square meters per gram, and pore volumes from 0.1 to 0.4 mL/gram can be used for purification processes. The metal oxide particles that fall within this range of physical properties show enhanced utility and greater chromatographic capacity for antibodies than materials oxide particles falling outside of this range. Metal oxides such as zirconia, titania and alumina can all be modified with a multi-Lewis base moiety such as an organophosphate ethylenediamine-N,N-tetra(methylenephosphonic) acid (EDTPA), to produce a bio-compatible purification media for, biomolecules.