The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 04, 2005
Filed:
Mar. 12, 2002
H. Ralph Snodgrass, Powell, OH (US);
Joseph Cioffi, New Albany, OH (US);
Thomas Joel Zupancic, Worthington, OH (US);
Alan Wayne Shafer, Lancaster, OH (US);
H. Ralph Snodgrass, Powell, OH (US);
Joseph Cioffi, New Albany, OH (US);
Thomas Joel Zupancic, Worthington, OH (US);
Alan Wayne Shafer, Lancaster, OH (US);
Indevus Pharmaceuticals, Inc., Lexington, MA (US);
Abstract
The present invention relates to methods for using various forms of a novel receptor expressed by hematopoietic and endothelial cells. An additional variant form of this receptor has been detected in brain cells and shown to bind to the obese gene product, leptin. Therefore, leptin may be used to stimulate the growth and development of receptor-positive hematopoietic and endothelial cells in vitro and in vivo. In addition, this receptor is selectively expressed in hematopoietic progenitor cells with long-term repopulating potential. Thus, agents that specifically bind to this receptor may be used to identify and isolate progenitor cells for a variety of clinical applications.