The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 07, 2004
Filed:
Apr. 05, 2002
Applicant:
Inventors:
John M. Greene, Gaithersburg, MD (US);
Craig A. Rosen, Laytonsville, MD (US);
Assignee:
Human Genome Sciences, Inc., Rockville, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/638 ; C07K 1/646 ; C12N 5/12 ;
U.S. Cl.
CPC ...
C07K 1/638 ; C07K 1/646 ; C12N 5/12 ;
Abstract
A human tissue inhibitor of metalloproteinases-4 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for the treatment of diseases, including arthritis and cancer. Antagonists against such polypeptides and their use as a therapeutic to resorb scar tissue are also disclosed. Diagnostic assays for detecting levels of human TIMP-4 protein and mutations in human TIMP-4 nucleic acid sequence are also disclosed.