The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 26, 2004
Filed:
Jan. 16, 2001
Applicant:
Inventors:
Anne N. Murphy, Encinitas, CA (US);
Amy K. Stout, Atlanta, GA (US);
Assignee:
MitoKor, Inc., San Diego, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/00 ; C12Q 1/68 ; C07H 2/107 ; C07H 2/104 ; A01N 6/100 ;
U.S. Cl.
CPC ...
C12Q 1/00 ; C12Q 1/68 ; C07H 2/107 ; C07H 2/104 ; A01N 6/100 ;
Abstract
The invention provides methods for screening for agents that modulate mitochondrial function and in particular mitochondrial regulation of intracellular calcium. The methods may be used to detect agents that bind to a mitochondrial calcium uniporter and may also detect inhibitors or uncouplers of mitochondrial respiration. Agents identified using the screens provided herein have application in the prevention and treatment of a variety of diseases associated with abnormal mitochondrial function.