The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 12, 2004
Filed:
Jun. 29, 2001
Applicant:
Inventors:
Roland Contreras, Merelbeke, BE;
Nico L. M. Callewaert, Lichtervelde, BE;
Steven C. J. Geysens, Kruishoutem, BE;
Assignee:
Flanders Interuniversity Institute for Biotechnology, Zwijnaarde, BE;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 1/14 ; C12N 1/16 ; C12N 1/500 ; C12N 1/574 ;
U.S. Cl.
CPC ...
C12N 1/14 ; C12N 1/16 ; C12N 1/500 ; C12N 1/574 ;
Abstract
The present invention provides genetically engineered strains of Pichia capable of producing proteins with reduced glycosylation. In particular, the genetically engineered strains of the present invention are capable of expressing either or both of an (&agr;-1,2-mannosidase and glucosidase II. The genetically engineered strains of the present invention can be further modified such that the OCH1 gene is disrupted. Methods of producing glycoproteins with reduced glycosylation using such genetically engineered stains of Pichia are also provided.