The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 12, 2004
Filed:
May. 10, 2001
Andreas Gerardus Uitterlinden, Poortugaal, NL;
Johannes Petrus Thomas Maria Van Leeuwen, Amstelveen, NL;
Huibert Adriaan Pieter Pols, Papendrecht, NL;
Erasmus Universiteit Rotterdam, Rotterdam, NL;
Abstract
The present invention relates to a prognostic method and means for determining susceptibility to bone damage in a subject, by screening for polymorphisms in the Vitamin D receptor or collagen I&agr;1 genes. In particular, the method for determining susceptibility to bone damage comprises analyzing the genetic material of a subject to determine which of the B/b, A/a or T/t alleles of the restriction enzyme sites BsmI, ApaI and TaqI respectively are present. The method may further comprise determining which allele is present at die SpI restriction site of the collagen I&agr;1 gene. Specific combinations of the above alleles represent a haplotype which is associated with susceptibility to bone damage.