The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 07, 2004
Filed:
Nov. 09, 2001
Applicant:
Inventors:
Peter John Ratcliffe, Oxford, GB;
Patrick Henry Maxwell, Oxford, GB;
Christopher William Pugh, Oxford, GB;
Assignee:
ISIS Innovation Limited, Oxford, GB;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q 1/54 ; G01N 3/353 ;
U.S. Cl.
CPC ...
C12Q 1/54 ; G01N 3/353 ;
Abstract
The invention relates to the finding that the VHL tumour suppressor protein regulates hypoxia inducible factor &agr; subunits, by targeting HIF &agr; for destruction in normoxic, but not hypoxic cells. The invention provides assays for modulators of this interaction, and peptides based upon HIF &agr; subunit sequence which may modulate this interaction.