The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 6770472 B1

PDF
Full Text
Expired
Date of Patent:
Aug. 03, 2004

Filed:

Nov. 13, 2001
Applicant:
Inventors:

Scott R. Manalis, Santa Barbara, CA (US);

Stephen C. Minne, Danville, IL (US);

Calvin F. Quate, Menlo Park, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12M 1/34 ; G01N 2/726 ;
U.S. Cl.
CPC ...
C12M 1/34 ; G01N 2/726 ;
Abstract

The present invention provides an apparatus and method for nucleotide or DNA sequencing by monitoring the molecular charge configuration as the DNA moves through a protein that is capable of transcribing the DNA. The apparatus and method provides a nanoscale electrometer that immobilizes the protein. The protein receives the DNA and transcribes the DNA. The nanoscale electrometer is a sensitive device that is capable of sensing and measuring the electronic charge that is released during the transcription process. The apparatus and method of the present invention further provides monitoring means that are attached to the nanoscale electrometer to monitor the electronic charge configuration as the DNA moves through the protein. Once the electronic charge configuration is established, a correlation is computed, using computing means, between the electronic charge configuration and a nucleotide signature of the DNA.


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Manalis, Scott. (2004). Direct dna sequencing with a transcription protein and a nanometer scale electrometer (U.S. Patent No. 6770472). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/6770472

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