The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 13, 2004
Filed:
Mar. 13, 2000
Andrew Roy Buchman, Berkeley, CA (US);
Darren Mark Platt, San Francisco, CA (US);
Michael Martin Ollman, Menlo Park, CA (US);
Lynn Marie Young, Redwood City, CA (US);
Madelyn Robin Demsky, San Francisco, CA (US);
Kevin Patrick Keegan, San Lorenzo, CA (US);
Lori Friedman, San Francisco, CA (US);
Casey Kopczynski, Belmont, CA (US);
Jeffrey S. Larson, Burlingame, CA (US);
Stephanie A. Robertson, San Francisco, CA (US);
Exelixis, Inc., South San Francisco, CA (US);
Abstract
A family of p53 tumor suppressor nucleic acid and protein isolated from several insect species is described. The p53 nucleic acid and protein can be used to genetically modify metazoan invertebrate organisms, such as insects and worms, or cultured cells, resulting in p53 expression or mis-expression. The genetically modified organisms or cells can be used in screening assays to identify candidate compounds that are potential pesticidal agents or therapeutics that interact with p53 protein. They can also be used in methods for studying p53 activity and identifying other genes that modulate the function of, or interact with, the p53 gene. Nucleic acid and protein sequences for Drosophila p33 and Rb tumor suppressors are also described.