The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 06, 2004
Filed:
Dec. 14, 1998
Fahad Al-Obeidi, Tucson, AZ (US);
Michal Lebl, Tucson, AZ (US);
James A. Ostrem, Tucson, AZ (US);
Pavel Safar, Tucson, AZ (US);
Alena Stierandova, Tucson, AZ (US);
Peter Strop, Tucson, AZ (US);
Armin Walser, Tucson, AZ (US);
Aventis Pharmaceuticals Inc., Bridgewater, NJ (US);
Abstract
The invention provides compounds which specifically inhibit factor Xa activity having the structure A —A —(A ) —B, where m is 0 or 1. A compound of the invention is characterized, in part, in that it exhibits a specific inhibition of factor Xa activity with a K ≦100 &mgr;M, preferably ≦2 nM, and does not substantially inhibit the activity of other proteases involved in the coagulation cascade. The invention further provides methods of specifically inhibiting the activity of factor Xa and of inhibiting blood clotting in vitro and in an individual and methods of detecting factor Xa levels or activity.