The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 18, 2004
Filed:
Jan. 18, 2001
Vitaliy Arkadyevich Livshits, Moscow, RU;
Vera Georgievna Doroshenko, Moscow, RU;
Nataliya Vasilyevna Gorshkova, Moscow, RU;
Alla Valentinovna Belaryeva, Moscow, RU;
Lirina Valeryevna Ivanovskaya, Moscow, RU;
Evgeni Moiseevich Khourges, Moscow, RU;
Valery Zavenovich Akhverdian, Moscow, RU;
Mikhail Markovich Gusyatiner, Moscow, RU;
Yury Ivanovich Kozlov, Moscow, RU;
Ajinomoto Co., Inc., Tokyo, JP;
Abstract
The present invention provides an isolated DNA molecule encoding a small subunit of acetohydroxy acid synthase isozyme III originating from and mutants of acetohydroxy acid synthase isozyme III, which are free from inhibition by L-valine an can catalyze the conversion of: (a) pyruvate to &agr;-acetolactate and (b) &agr;-ketobutyrate and pyruvate to &agr;-aceto-a-hydroxybutyrate. The present invention also provides methods for producing L-valine by fermentation of a bacterium harboring the novel DNA molecule and/or expressing the mutant acetohydroxy acid synthase isozyme III.