The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 20, 2004
Filed:
Dec. 12, 2001
James A. Sikorski, Des Peres, MI (US);
Richard C. Durley, Chesterfield, MI (US);
Margaret L. Grapperhaus, Troy, IL (US);
Mark A. Massa, Ballwin, MI (US);
Emily J. Reinhard, Chesterfield, MI (US);
Yvette M. Fobian, Labadie, MI (US);
Michael B. Tollefson, O'Fallon, MI (US);
Lijuan Wang, Wildwood, MI (US);
Brian S. Hickory, Wildwood, MI (US);
Monica B. Norton, St. Louis, MI (US);
William F. Vernier, St. Louis, MI (US);
Deborah A. Mischke, Defiance, MI (US);
Michele A. Promo, Chesterfield, MI (US);
Ashton T. Hamme, St. Louis, MI (US);
Dale P. Spangler, Deerfield, MI (US);
Melvin L. Rueppel, St. Louis, MI (US);
Pharmacia Corporation, St. Louis, MO (US);
Abstract
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1 )-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Novel high yield, stereoselective processes for the preparation of the chiral substituted alkanol compounds from chiral and achiral intermediates are described. Preferred (R)-Chiral 1-Substitutedamino-(n+1)-Alkanol compounds are substituted (R)-Chiral N-benzyl-N-phenyl aminoalcohols. A preferred specific (R)-Chiral N-benzyl-N-phenyl aminoalcohol is the compound: