The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 16, 2004
Filed:
Sep. 26, 2002
Applicant:
Inventors:
Carlin Long, Denver, CO (US);
Eric N. Olson, Dallas, TX (US);
Michael Bristow, Cherry Hills Village, CO (US);
Timothy A. McKinsey, Broomfield, CO (US);
Assignee:
The Regents of the University of Colorado, Boulder, CO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/800 ; A61K 3/144 ; A61K 3/1335 ; A61K 3/1165 ; A61K 3/1135 ; A61K 4/900 ; G01N 3/348 ;
U.S. Cl.
CPC ...
A61K 3/800 ; A61K 3/144 ; A61K 3/1335 ; A61K 3/1165 ; A61K 3/1135 ; A61K 4/900 ; G01N 3/348 ;
Abstract
The present invention provides for methods of treating and preventing cardiac hypertrophy. Class II HDACs, which are known to participate in regulation of chromatin structure and gene expression, have been shown to have beneficial effects on cardiac hypertrophy. Surprisingly, the present invention demonstrates that HDAC inhibitors inhibit cardiac hypertrophy by inhibiting fetal cardiac gene expression and interfering with sarcomeric organization.