The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 30, 2003
Filed:
Apr. 05, 2001
Carles Farrerons Gallemi, Canyamars, ES;
Ignacio-José Miquel Bono, L'Hospitalet de Llobregat, ES;
Ana Maria Fernandez Serrat, Barcelona, ES;
Carlos Monserrat Vidal, Barcelona, ES;
Carmen Lagunas Arnal, L'Hospitalet de Llobregat, ES;
Ferran Gimenez Guasch, Barcelona, ES;
Andrés Fernandez Garcia, Barcelona, ES;
Laboratorios S.A.L.V.A.T., S.A., Esplugues de Llobregat, ES;
Abstract
The invention refers to new compounds of formula (I), wherein A and B are selected from the group consisting of N and CH, with the condition that when A is N, B is N; R is selected from the group consisting of CH and NH ; R and R are selected from the group consisting of H, CH , Br, Cl, COCH and OCH ; and R , R and R , are selected from the group consisting of H, F, Cl, Br, (C1-C3)-alkyl, trifluoromethyl, (C1-C3)-alkoxy and trifluoromethoxy. Compounds of formula (I) are prepared by reaction of a substituted aminoazine with a substituted 2-bromo-2-(4-R -sulfonylphenyl)-1-phenylethanone in a polar solvent. These new compounds inhibit COX-2 with high selectivity over COX-1. They are useful for the treatment of inflamation and/or cyclooxygenase-mediated diseases, having the additional advantage of a reduced potencial for ulcerogenic effects.