The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 02, 2003
Filed:
Apr. 09, 2001
Anthony M. Manning, Lake St. Louis, MO (US);
Frank Mercurio, San Diego, CA (US);
Sharon Amit, Beer-Sheba, IL;
Yinon Ben-Neriah, Zion, IL;
Matti Davis, Jerusalem, IL;
Ada Hatzubai, Kibutz Palmah-Zova, IL;
Avraham Yaron, Jerusalem, IL;
Irit Alkalay, Jerusalem, IL;
Aaron Ciechanover, Haifa, IL;
Signal Pharmaceuticals, Inc., San Diego, CA (US);
Abstract
Compositions and methods for modulating the activation of nuclear factor &kgr;B (NF-&kgr;B) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated I&kgr;B&agr; and/or I&kgr;B&bgr;. Such compositions may be used for treating diseases associated with NF-&kgr;B activation. Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins.