The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 21, 2003
Filed:
Jul. 30, 2001
Applicant:
Inventors:
Yuqiao Shen, Richmond, CA (US);
Julie Nye, Berkeley, CA (US);
Terry Hermiston, Corte Madera, CA (US);
Assignee:
Onyx Pharmaceuticals, Inc., Richmond, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A01N 6/300 ; C12N 7/00 ; C12N 1/500 ; C12N 1/564 ; C12P 2/106 ;
U.S. Cl.
CPC ...
A01N 6/300 ; C12N 7/00 ; C12N 1/500 ; C12N 1/564 ; C12P 2/106 ;
Abstract
Adenoviral mutants are described that have single amino acid mutations in the E1B-55K protein which mutations effect the p53 binding/inactivation and the late functions of the E1B-55K protein in a manner that enhances the efficacy of such viruses for treating cancer when compared to adenoviral mutants that have the E1B-55K region deleted.