The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2003
Filed:
Nov. 09, 2001
Jeffrey Shuster, Chapel Hill, NC (US);
Matthew M. Tanzer, Durham, NC (US);
Lisbeth Hamer, Durham, NC (US);
Kiichi Adachi, Durham, NC (US);
Todd M. DeZwaan, Apex, NC (US);
Sze-Chung Lo, Durham, NC (US);
Maria Victoria Montenegro-Chamorro, Morrisville, NC (US);
Blaise Darveaux, Hillsborough, NC (US);
Sheryl Frank, Durham, NC (US);
Ryan Heiniger, Raleigh, NC (US);
Sanjoy K. Mahanty, Chapel Hill, NC (US);
Huaqin Pan, Apex, NC (US);
Amy Skalchunes, Raleigh, NC (US);
Rex W. Tarpey, Apex, NC (US);
Paradigm Genetics, Inc., Research Triangle Park, NC (US);
Abstract
The present inventors have discovered that homocitrate synthase is essential for fungal pathogenicity. Specifically, the inhibition of homocitrate synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, homocitrate synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit homocitrate synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.