The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2003
Filed:
Jul. 31, 2000
Use of the crystal structure of staphylococcus aureus isoleucyl-trna synthetase in antibiotic design
Applicant:
Inventors:
Jimin Wang, Hamden, CT (US);
Laura F. Silvian, Newton, MA (US);
Thomas A. Steitz, Branford, CT (US);
Assignee:
Yale University, New Haven, CT (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G06F 1/900 ; G01N 3/348 ; C12Q 1/48 ; C12N 9/10 ; C12N 1/511 ;
U.S. Cl.
CPC ...
G06F 1/900 ; G01N 3/348 ; C12Q 1/48 ; C12N 9/10 ; C12N 1/511 ;
Abstract
The present invention provides the atomic coordinates derived from high resolution x-ray diffraction of the cocrystal complex comprising mupirocin with its target enzyme, isoleucyl-tRNA synthetase from , and the cognate tRNA from . The present invention further provides methods of using the atomic coordinates to identify and design new agents which modulate protein synthesis as well as the agents themselves.