The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 2003
Filed:
Jun. 21, 1999
Applicant:
Inventors:
Ole Buchardt, late of Værløse, DK;
Michael Egholm, Lexington, MA (US);
Peter Eigil Nielsen, Kokkedal, DK;
Rolf Henrik Berg, Kyst, DK;
Assignee:
ISIS Pharmaceuticals, Inc., Carlsbad, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/800 ; C12Q 1/68 ; A01N 3/718 ; A01N 4/304 ;
U.S. Cl.
CPC ...
A61K 3/800 ; C12Q 1/68 ; A01N 3/718 ; A01N 4/304 ;
Abstract
A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and binding affinity. The peptide nucleic acids of the invention comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone. Some PNAs of the invention also contain C -C alkylamine side chains.