The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2003
Filed:
Apr. 14, 2000
Applicant:
Inventors:
Charlotta Ljungqvist, Bromma, SE;
Karin Nord, Stockholm, SE;
Per-Åke Nygren, Skarpnäck, SE;
Mathias Uhlén, Täby, SE;
Assignee:
Biovitrum AB, Stockholm, SE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/800 ; C07K 1/600 ; C07K 5/00 ; C07K 1/00 ;
U.S. Cl.
CPC ...
A61K 3/800 ; C07K 1/600 ; C07K 5/00 ; C07K 1/00 ;
Abstract
The present invention relates to modified polypeptide derivatives of the B domain or Z domain of staphylococcal protein A (SPA). The derivatives contain amino acid substitutions that result in the ability of the B domain or Z domain to interact with at least one domain of a human Factor VIII protein, without substantially disrupting the structure and stability of the B domain or Z domain.