The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 08, 2003
Filed:
Feb. 26, 1999
Ho-Joon Choi, Daejon, KR;
Hyung-Kyoon Choi, Daejon, KR;
Sang-Ic Kim, Daejon, KR;
Jeong-Hwan Yun, Daejon, KR;
Joo-Sun Son, Daejon, KR;
Moon-Seok Chang, Daejon, KR;
Eunsoo Choi, Daejon, KR;
Hong-Rak Kim, Daejon, KR;
Seung-Suh Hong, Daejon, KR;
Hyun-Soo Lee, Daejon, KR;
Samyang Genex Corporation, Seoul, KR;
Abstract
The present invention relate to a method to increase the production level of paclitaxel by changing the temperature during the plant cell culture. According to the present invention, the production of the paclitaxel comprises the following procedure: (i) cultivating the Taxus genus plant cells in a medium at ca. 20 to 25° C.; and (ii) when growth of the plant cells has progressed sufficiently, changing the cultivation temperature to ca. 26 to 32° C. to continue the culture. The present invention comprises also the method of increasing the paclitaxel production by inoculating the cells at a high initial concentration and by increasing the saccharide concentration in the medium: According to the present invention, paclitaxel can be mass-produced conveniently and therefore has an industrial application.