The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 08, 2003
Filed:
Jan. 14, 2000
Martine F. Roussel, Memphis, TN (US);
Richard Smeyne, Collierville, TN (US);
Frederique Zindy, Memphis, TN (US);
Justine Cunningham, Memphis, TN (US);
Neil Segil, Altadena, CA (US);
Ping Chen, Arcadia, CA (US);
St. Jude Children's Research Hospital, Memphis, TN (US);
Abstract
Non-human animals that have been manipulated so as not to express a functional p19 and p27 proteins are described. One particular non-human animal exemplified is a p19 -double null, p27 -double null mouse. Such knockout mice exhibit bradykinesia, proprioceptive abnormalities, seizure-like activity, and generally die 14-24 days after birth. In addition, mammalian cells having the p19 -double null, p27 -double null genotype are characterized. Methods of making and using the non-human knockout animals and cells are disclosed.