The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 10, 2003
Filed:
Oct. 20, 1999
Roland E. Dolle, King of Prussia, PA (US);
Irennegbe K. Osifo, W. Norriton, PA (US);
Stanley J. Schmidt, Chester Springs, PA (US);
Denton W. Hoyer, Exton, PA (US);
Tina Morgan Ross, Audubon, PA (US);
Prasad V. Chaturvedula, Cheshire, CT (US);
Catherine P. Prouty, Doylestown, PA (US);
Mohamed M. A. Awad, Westerly, RI (US);
Joseph M. Salvino, Schwenksville, PA (US);
James M. Rinker, Hamden, CT (US);
Eric P. Lodge, Glendale, AZ (US);
Jasbir Singh, Gilbertsville, PA (US);
Mark A. Ator, Paoli, PA (US);
Vertex Pharmaceuticals Incorporated, Cambridge, MA (US);
Abstract
Disclosed are compounds, compositions, and methods for inhibiting interleukin-1&bgr; protease activity, wherein the compounds are &agr;-substituted methyl ketones having formula (I) as set forth herein. These compounds are inhibitors of IL-1&bgr; converting enzyme and as such are useful as therapeutic agents for certain infectious diseases.