The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2003
Filed:
Jun. 07, 2000
George A. Keesler, Sommerville, NJ (US);
Cesare Mondadori, Basking Ridge, NJ (US);
Zhengbin Yao, Whitehouse Station, NJ (US);
Fernando Camacho, Union, NJ (US);
Aventis Pharmaceuticals Inc., Bridgewater, NJ (US);
Abstract
The present invention is directed to methods to identify test compounds that alter circadian rhythms of mammals, and more specifically, directed to methods for determining the ability of a test compound to alter hCKI &dgr; and &egr; phosphorylation of a human Period protein. The present invention is also directed to a method for determing the ability of a test compound to selectively alter phosphorylation, interaction with, or alternatively degradation, of one or more human Period proteins relative to its ability to alter phosphorylation, interaction with, or alternatively degradation, of a different human Period protein.