The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 01, 2003
Filed:
Mar. 24, 2000
Applicant:
Inventor:
David Modrak, Nutley, NJ (US);
Assignee:
Center for Molecular Medicine and Immunology, Belleville, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 5/726 ; A01N 4/304 ; A61K 5/100 ;
U.S. Cl.
CPC ...
A01N 5/726 ; A01N 4/304 ; A61K 5/100 ;
Abstract
Cytotoxic tumor therapy in a patient is enhanced by co-administration of sphingomyelin. The invention most likely enhances a tumor cell's ability to undergo ceramide-induced apoptosis by increasing the levels of sphingomyelin in all cellular compartments, thereby providing sufficient substrate for activated sphingomyelinase. A method of treating rheumatoid arthritis also is provided.