The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 2002
Filed:
Dec. 01, 1999
Applicant:
Inventors:
Mauro Biffoni, Rome, IT;
Ruben Papoian, Villars-sous-Yens, CH;
Assignee:
Applied Research Systems ARS Holding N.V., Curacao, NL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 4/800 ; C12N 5/00 ; C12N 5/08 ; C12N 1/563 ;
U.S. Cl.
CPC ...
A61K 4/800 ; C12N 5/00 ; C12N 5/08 ; C12N 1/563 ;
Abstract
A method to prevent graft rejection of transplanted cells, tissues or organs without general immunosuppression is described. The method employs a newly discovered protein, LAG-3. When allogeneic or xenogeneic cells are engineered to express LAG-3 on their surface and transplanted, immune destruction of the implanted cell, tissue or organ is prevented, while the host's immune system remains functional. A particular application of this method allows the preparation of a universal gene therapy host cell expressing LAG-3 on its surface for protection from graft rejection by a host's immune system.