The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 12, 2002
Filed:
May. 03, 2001
Applicant:
Inventor:
Nicholas K. Tonks, Cold Spring Harbor, NY (US);
Assignee:
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 1/600 ; C07K 1/618 ; C07K 1/640 ;
U.S. Cl.
CPC ...
C07K 1/600 ; C07K 1/618 ; C07K 1/640 ;
Abstract
An antibody is provided that is specific for a PTPH1 protein, a phosphatase that dephosphorylates phosphotyrosine residues in phosphoproteins having tyrosyl residues that are phosphorylated by tyrosine kinases. The PTPH1 protein localizes to focal adhesions, a major site of action for oncogenic protein tyrosine kinases. PTPH1 overexpression may counter the effects of oncogenic protein tyrosine kinases, such as those of transforming viruses, by interfering with or reversing cell transformation that is associated with the activity of a protein tyrosine kinase.