The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 05, 2002
Filed:
Jun. 02, 1997
Stephen J. Lippard, Cambridge, MA (US);
John M. Essigmann, Cambridge, MA (US);
Brian A. Donahue, Menlo Park, CA (US);
Jeffrey H. Toney, Basking Ridge, NJ (US);
Suzanne L. Bruhn, Mansfield, MA (US);
Pieter M. Pil, New Haven, CT (US);
Steven J. Brown, San Diego, CA (US);
Patti J. Kellett, West Chester, OH (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
Methods disclosed herein capitalize on the ability of DNA Structure Specific Recognition Proteins (SSRPs) to bind to genomic lesions formed by chemotherapeutic agents, particularly cisplatin-type agents. Methods are provided for predicting whether an agent that damages DNA will also be cytotoxic, and for predicting whether particular eukaryotic cells will be susceptible to killing by a genotoxic drug. A screening method is provided for identifying new genotoxic drugs that produce SSRP-recognized lesions in DNA. Methods also are provided for sensitizing particular eukaryotic cells to killing by chemotherapeutic agents, particularly cisplatin-type drugs.