The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 22, 2002
Filed:
Jul. 21, 2000
Applicant:
Inventors:
Ronald N. Zuckermann, Berkeley, CA (US);
Nathalie Dubois-Stringfellow, Berkeley, CA (US);
Varavani Dwarki, Alameda, CA (US);
Michael A. Innis, Moraga, CA (US);
John E. Murphy, Oakland, CA (US);
Fred E. Cohen, San Francisco, CA (US);
Tetsuo Uno, San Francisco, CA (US);
Assignee:
Chiron Corporation, Emeryville, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 4/800 ;
U.S. Cl.
CPC ...
A61K 4/800 ;
Abstract
This invention relates compositions and methods for increasing the uptake of polynucleotides into cells. Specifically, the invention relates to vectors, targeting ligands, and polycationic agents. The polycationic agents are capable of (1) increasing the frequency of uptake of polynucleotides into a cell, (2) condensing polynucleotides; and (3) inhibiting serum and/or nuclease degradation of polynucleotides.