The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2002
Filed:
Dec. 24, 1998
Matthias Kottenhahn, Freigericht, DE;
Roland Möller, Hammersbach, DE;
Michael Kraft, Rodenbach, DE;
Karlheinz Drauz, Freigericht, DE;
Klaus Stingl, Alzenau, DE;
Degussa Aktiengesellschaft, Frankfurt, DE;
Abstract
A method of isolating 1-[N -((S)-ethoxycarbonyl)-3-phenylpropyl)-N -trifluoroacetyl]-L-lysyl-L-proline (lisinopril (TFA) ethyl ester, LPE). The solvent or solvent mixture used for the extraction is also a main constituent of the solvent or solvent mixture from which the crystallization takes place. High yield as well as good purity of the end product are obtained, without distillation. 1-[N -((S)-ethoxycarbonyl)-3-phenylpropyl)-N -trifluoroacetyl]-L-lysyl-L-proline (lisinopril (TFA) ethyl ester, LPE) is described as a precursor for producing an ACE inhibitor.