The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2002
Filed:
Nov. 03, 2000
Applicant:
Inventors:
Kurt Jarnigan, San Mateo, CA (US);
Roger Leger, Saint-Lambert, CA;
Ving J. Lee, Los Altos, CA (US);
David Morgans, Los Altos, CA (US);
Assignee:
Iconix Pharmaceuticals Inc., Mountain View, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/34 ; C12Q 1/26 ; C12Q 1/00 ; G01N 3/353 ;
U.S. Cl.
CPC ...
C12Q 1/34 ; C12Q 1/26 ; C12Q 1/00 ; G01N 3/353 ;
Abstract
Compounds of the invention have the structure D—L—A*, where L is a linking moiety that maintains D and A in a configuration compatible with FRET, D is a fluorescent donor moiety capable of causing an acceptor moiety to fluoresce by FRET, and A* is a fluorescent acceptor moiety capable of accepting energy from the donor moiety by FRET and fluorescing only after cleavage of one or more labile groups to provide acceptor A. These compounds are useful as fluorescent substrates for detection of enzymes in vivo.