The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2002
Filed:
Nov. 16, 1998
Wolfgang Strittmatter, Ober-Ramstadt, DE;
Siegfried Matzku, Zwingenberg, DE;
Dieter Riesenberg, Jena, DE;
Uwe Horn, Bad Frankenhausen, DE;
Uwe Knüpeer, Jena, DE;
Marian Kujau, Jena, DE;
Rolf Wenderoth, Jena, DE;
Andreas Plückthun, Zürich, CH;
Anke Krebber, Zürich, CH;
Merck Patent Gesellschaft, Darmstadt, DE;
Abstract
The invention relates to a fed-batch fermentation process which uses special host/vector systems for the purpose of efficiently forming recombinant proteins, in particular recombinant antibody molecules, preferably antibody fragments such as miniantibodies. Under the given conditions, the cells are able to grow at a maximum specific growth rate up to very high cell densities. After the recombinant product formation has been switched on, it is only the formed product which restricts growth; there is no growth restriction due to substrates or metabolic by-products. High space-time yields of recombinant proteins can be achieved in this manner.