The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2002
Filed:
Jun. 26, 1997
Applicant:
Inventors:
Thomas F. Zioncheck, Montara, CA (US);
Geralyn G. DeGuzman, Daly City, CA (US);
Rodney G. Keck, Castro Valley, CA (US);
Brigitte M. Richard, La Jolla, CA (US);
Nishit B. Modi, San Bruno, CA (US);
Assignee:
Genentech, Inc., So. San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/4475 ; A61K 3/818 ;
U.S. Cl.
CPC ...
C07K 1/4475 ; A61K 3/818 ;
Abstract
Described herein are vascular endothelial cell growth factor (VEGF) variants having structural alterations in the C-terminus heparin binding domain and methods of use. The variants exhibit reduced clearance rates for systemic administration generally at lower doses compared with native VEGF thus providing variants having longer availability for therapeutic effect.