The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 21, 2002

Filed:

May. 17, 1996
Applicant:
Inventors:

Kevin P. Anderson, Carlsbad, CA (US);

Ronnie C. Hanecak, San Clemente, CA (US);

Kazuya Hoshiko, Kumamoto, JP;

Chikateru Nozaki, Kumamoto, JP;

Tsukasa Nishihara, Kumamoto, JP;

Hiroshi Nakatake, Kikuyo-machi, JP;

Fukusaburo Hamada, Nishigoshi-machi, JP;

Tatsuo Eto, Ohzu-machi, JP;

Shinichi Furukawa, Koshi-machi, JP;

Shoji Furasako, Tokyo, JP;

Thomas W. Bruice, Carlsbad, CA (US);

Walter F. Lima, San Diego, CA (US);

Assignee:

Isis Pharmaceuticals, Inc., Carlsbad, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 ; C07H 2/104 ; C12N 1/585 ; C12P 1/934 ;
U.S. Cl.
CPC ...
C12Q 1/68 ; C07H 2/104 ; C12N 1/585 ; C12P 1/934 ;
Abstract

Antisense oligonucleotides are provided which are complementary to and hybridizable with at least a portion of HCV RNA and which are capable of inhibiting the function of the HCV RNA. These oligonucleotides can be administered to inhibit the activity of Hepatitis C virus in vivo or in vitro. These compounds can be used either prophylactically or therapeutically to reduce the severity of diseases associated with Hepatitis C virus, and for diagnosis and detection of HCV and HCV-associated diseases. Methods of using these compounds are also disclosed.


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