The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 16, 2002

Filed:

Feb. 19, 1999
Applicant:
Inventors:

Robert Henry Hesse, Winchester, MA (US);

Maurice Murdoch Pechet, Cambridge, MA (US);

Sundara Katugam Srinivasasetty Setty, Cambridge, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C / ; A61K 3/1593 ;
U.S. Cl.
CPC ...
C07C / ; A61K 3/1593 ;
Abstract

1-Hydroxy pregnacalciferol derivatives of formula (I) and their corresponding 5,6-trans isomers wherein R is hydroxyl or lower alkoxy and R is optionally hydroxylated or lower alkoxylated lower alkynyl or R is C(R ) (R )CH where R is optionally hydroxylated or lower alkoxylated lower alkynyl and R is hydroxyl or lower alkoxy or R and R together represent oxo and R is hydrogen, hydroxyl or lower alkoxy, and R and R represent hydrogen atoms, exhibit anti-progesterone activity and may be useful as antineoplastic, antifertility, antiproliferative, immunosuppressive and/or antiinflammatory agents.


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